Endocrine Abstracts

Background and aims: Irisin is a novel myokine that promote energy expenditure. It could act on adipocyte metabolism through a novel neural pathway and on the other hand irisin induces neural proliferation and adequate neural differentiation. We aimed to assess serum irisin level in type 2 diabetics (T2DM) and correlate it with metabolic parameters. Also, we assessed the relation between irisin level and diabetic peripheral neuropathy (DPN).Methods: We r...

Background: Hashimoto’s thyroiditis is one of the leading causes of hypothyroidism worldwide. Currently the only available treatment is Levothyroxine. Even though symptoms improve with treatment, many patients continue to suffer from a lower quality of life and inability to lose weight. The role of nutritional therapy in managing patients with Hashimoto’s disease has been of interest lately.Aim: The aim of our study was to assess the effects of...

There is evidence that vitamin D has a variety of effects on immune system function, which may enhance innate immunity and inhibit the development of autoimmunity. It suppresses T-cell proliferation, and inhibits secretion of pro-inflammatory Th1- and Th2-related Cytokines. In Graves’ ophthalmopathy (GO), a diffuse infiltration of lymphocytes is seen in the orbital adipose tissues and extracellular muscles. Th1 and 2 appear to play a role GO.Aim: To...

Background: Chronic kidney disease secondary to type 2 diabetes is associated with multifactorial energy dysmetabolism. Irisin has been identified recently as an exercise induced hormone secreted by skeletal muscles. It is hypothesised that patients with CKD may have altered irisin levels.Aim of the work: We aimed to study irisin hormone in type 2 diabetic patient and to assess its relation with diabetic nephropathy (DN).Subjects a...

Introduction: Increased visceral adiposity is usually associated with a clustering of atherogenic risk factors, such as insulin resistance, hypertension, dyslipidemia, alterations in coagulation and inflammatory cytokine profiles. Visceral adipose tissue derived serpin (Vaspin) is an adipokine with insulin sensitizing effect which is markedly elevated in high body mass index (BMI) people.Aim: To evaluate serum Vaspin level in relation to atherogenic risk...

A 65 year old female presented to ER with progressive massive lower limb oedema and dyspnea on mild exertion of insidious onset. The patient started to complain of progressive lower limb oedema shortly after her discharge from Hospital ICU in June 2020 where she was being treated for severe COVID-19. She presented then with acute kidney injury, generalized oedema and was diagnosed with COVID-19 based on clinical, laboratory criteria, PCR, and CT findings. She is a known patien...

Background: Atherosclerotic cardiovascular disease (ASCVD) is a major complication to type 2 diabetes (T2D), in terms of both severity and prevalence rates. The Prevalence and clinical management of the Atherosclerotic Cardiovascular Diseases in patients with Type 2 Diabetes across Middle East and Africa countries (PACT-MEA) is a multinational study that aimed to investigate the prevalence of both established ASCVD and the risk for ASCVD in people with T2D as well as its clini...